Program

Global Conference on Pulmonology and Respiratory Medicine | September 29, 30 - October 01, 2022 | Online

Seema Singh

King Georges Medical University, India

Abstract:

Background: Inflammation plays an important role in chronic obstructive pulmonary disease (COPD). Increasing evidence points to the role of inflammation in the pathogenesis of type 2 diabetes (T2D).

Aim & objectives: We intend to investigate the biomarkers in Adiponectin; Leptin and IL-8 gene for COPD-induced T2DM patients. Along with this, we analyzed the effect of polymorphism on the levels of these cytokines.

Material & methods: A total of 500 subjects including 250 controls, 191 COPD and 59 COPD with T2DM each, aged 30 to 70 years were enrolled for the study after meeting the inclusion criteria. Written informed consent was obtained from each subject before inclusion in the study. The study was approved by the institutional ethics committee (ethical no 90 TH ECM IIB-FS/P2.).

Results: We found statistically significant results of serum biomarkers in all studied groups.
Leptin, Adiponectin and IL-8 in serum levels were significantly higher with a p-value (0.001) in COPD with diabetes when compared with COPD and healthy controls. Genotyping of Leptin (C/T), Adiponectin (C/G) and IL-8 (C/T) polymorphisms were performed. Genotype frequency of ‘CT’ of Leptin gene variant was showing significant association with risk of developing COPD by 3.7 folds. But it was not associated witGeh development of T2DM in COPD cases. Whereas genotype ‘TT’ was highly significant association with risk of developing T2DM in COPD patients by 2.4 folds. This means individuals with genotype ‘TT’ are at higher risk of developing of COPD and moreover they are at risk of T2DM.

Conclusion: We also conclude that genotype ‘TT’ of Leptin, ‘GG’ of Adiponectin and ‘TT’ of IL-8 may be exploited as biomarker for prognosis and diagnosis of T2DM in COPD and COPD respectively. While ‘CT’ of IL-8 was protective biomarker against COPD.

 

Biography:

Dr. Seema Singh has completed her PhD at the age of 32 years from King Georges Medical University, UP, Lucknow, India. She is working as Young Scientist, ICMR-DHR in the Department of Respiratory Medicine, king Georges Medical University, India. She has published more than 40 original research articles/ review papers in reputed journals and has been serving as an editorial board member of repute. She has been awarded 3 fellowships from reputed Research institutes like, UGC- New Delhi, ICMR-New Delhi, HRD-DHR-New Delhi, she has also been awarded as oral and poster presentation in many national and internationals conferences.